The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis

Abstract The development of granulomas with central necrosis harboring Mycobacterium tuberculosis (Mtb) stagg sdm70 is the hallmark of human tuberculosis (TB).New anti-TB therapies need to effectively penetrate the cellular and necrotic compartments of these lesions and reach sufficient concentrations to eliminate Mtb.BTZ-043 is a novel antibiotic

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Interlimb Transfer of Grasp Orientation is Asymmetrical

One the most fundamental aspects of the human motor system is the hemispheric asymmetry seen in behavioral specialization.Hemispheric dominance can be inferred by a contralateral hand preference in grasping.Few studies have considered grasp orientation in the context of manual lateralization and none has looked at grasp orientation with natural pre

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Development of a Risk Model and Genotyping Patterns Based on Disulfidptosis-Related lncRNAs to Predict Prognosis and Immune Landscape in Osteosarcoma

Background: Osteosarcoma (OS) is the most prevalent orthopedic malignancy with a dismal prognosis.Disulfidptosis-related lncRNAs (DRLncs) may be related to the progression of OS, but their potential molecular regulatory role is still unclear.Methods: Based on the data collected from The Cancer Genome Atlas (TCGA), we conducted correlation analysis

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